LearnFor BusinessEnterprise GPU Security
Enterprise Guide
15 min read

Enterprise GPU SecurityProtecting AI Infrastructure at Scale

A comprehensive guide to securing GPU compute for enterprise AI workloads. Compliance frameworks, threat models, and best practices for SOC2, HIPAA, and GDPR.

4
Compliance
Frameworks covered
16+
Threats
Attack vectors
20+
Controls
Security measures
15
Checklist
Action items
G
Griddly Security Team
Updated December 2025

Overview

As AI becomes mission-critical for enterprises, securing GPU infrastructure is no longer optional. Whether you're training proprietary models, processing sensitive data, or deploying AI at scale, security must be built into every layer.

This guide covers the complete security landscape for enterprise GPU compute — from compliance frameworks to technical controls, with specific guidance for distributed GPU platforms like Griddly.

Why GPU Security Matters

  • Data at Risk: Training data often contains PII, trade secrets, or regulated information
  • Model Value: AI models represent millions in R&D investment
  • Compliance: Regulatory requirements mandate specific security controls
  • Reputation: A breach can destroy customer trust instantly

Threat Model

Understanding potential attack vectors is the first step to securing your GPU infrastructure:

Data Exfiltration

Critical
Threats
  • Training data leakage
  • Model weights extraction
  • Inference data capture
  • Side-channel attacks
Mitigations
  • End-to-end encryption
  • Secure enclaves (TEE)
  • Data access logging
  • Network isolation

Unauthorized Access

Critical
Threats
  • Credential compromise
  • Privilege escalation
  • API key exposure
  • Session hijacking
Mitigations
  • MFA enforcement
  • RBAC policies
  • API key rotation
  • Zero-trust architecture

Infrastructure Attacks

High
Threats
  • DDoS on GPU clusters
  • Container escapes
  • Hypervisor exploits
  • Supply chain attacks
Mitigations
  • DDoS protection
  • Container hardening
  • Regular patching
  • Vendor verification

Model Attacks

High
Threats
  • Model poisoning
  • Adversarial inputs
  • Model inversion
  • Membership inference
Mitigations
  • Input validation
  • Differential privacy
  • Model watermarking
  • Anomaly detection

Compliance Frameworks

Different industries require different compliance certifications. Here's what you need to know:

SOC 2 Type II

Security, availability, processing integrity, confidentiality, and privacy controls.

KEY REQUIREMENTS
Access controls
Encryption at rest/transit
Audit logging
Incident response

HIPAA

Healthcare data protection for AI models processing PHI.

KEY REQUIREMENTS
BAA agreements
PHI encryption
Access audit trails
Breach notification

GDPR

EU data protection for AI training on personal data.

KEY REQUIREMENTS
Data minimization
Right to erasure
DPA agreements
Cross-border transfers

ISO 27001

Information security management system certification.

KEY REQUIREMENTS
Risk assessment
Security policies
Asset management
Continuous improvement

Griddly Compliance

Griddly maintains SOC 2 Type II certification and supports HIPAA-compliant workloads with BAA agreements. Our infrastructure is designed for regulated industries.

Data Security

Data is your most valuable asset. Here's how to protect it throughout the AI lifecycle:

Network Security

  • Private VPC deployment
  • TLS 1.3 encryption
  • DDoS protection
  • Firewall rules
  • VPN/Direct Connect

Data Security

  • AES-256 encryption at rest
  • TLS encryption in transit
  • Secure key management (HSM)
  • Data classification
  • Secure deletion

Encryption Best Practices

AES-256
At Rest
TLS 1.3
In Transit
HSM
Key Management

Access Control

Zero-trust access control is essential for enterprise GPU security:

Access Control

  • SSO integration (SAML/OIDC)
  • Multi-factor authentication
  • Role-based access control
  • API key management
  • Session management

Monitoring & Audit

  • Real-time threat detection
  • Comprehensive audit logs
  • SIEM integration
  • Anomaly alerting
  • Compliance reporting

API Key Security

API keys are the most common attack vector. Follow these rules:

  • • Never commit keys to version control
  • • Rotate keys every 90 days minimum
  • • Use environment variables or secrets managers
  • • Implement key scoping (read-only, specific resources)

Distributed Computing Security

Distributed GPU platforms like Griddly require additional security considerations:

ConcernTraditional CloudDistributed (Griddly)
Provider TrustSingle vendorVerified providers + isolation
Data ExposureProvider has accessZero-knowledge encryption
Workload IsolationVMs/containersContainers + secure enclaves
Network SecurityVPCEncrypted tunnels + VPN
Audit TrailCloudTrail/equivalentImmutable blockchain logs

Griddly Security Architecture

Griddly was built with enterprise security as a core requirement:

Workload Isolation

Every job runs in an isolated container with no shared memory or storage between workloads.

End-to-End Encryption

Data encrypted from upload to processing to download. Keys never leave your control.

Zero-Knowledge Architecture

Griddly cannot access your data or model weights. Only you hold the decryption keys.

Verified Providers

All GPU providers undergo identity verification and hardware attestation.

Audit Logging

Complete audit trail of all API calls, data access, and job execution.

SOC 2 Compliance

Annual SOC 2 Type II audits verify our security controls and practices.

Security Checklist

Use this checklist to ensure your GPU infrastructure is properly secured:

Before Deployment

  • Classify data sensitivity (PII, PHI, confidential)
  • Review compliance requirements
  • Assess vendor security certifications
  • Define access control policies
  • Plan encryption strategy

During Operation

  • Enable MFA for all users
  • Rotate API keys regularly
  • Monitor audit logs
  • Review access permissions quarterly
  • Test incident response procedures

Data Handling

  • Encrypt data before upload
  • Use secure transfer protocols
  • Implement data retention policies
  • Secure deletion after processing
  • Maintain data lineage records

Enterprise-Ready GPU Compute

Griddly provides SOC 2 compliant GPU compute with enterprise-grade security. Get the performance you need without compromising on security.